Evaluation of Hepatoprotective Potential of Stem Bark of Neolamarckia cadamba against Chloroform and Over dose of Iron Dextran Induced Hepatotoxicity in Experimental Swiss Albino Mice

Abstract: Background: In general, use of herbal medicines are considered as the backbone in traditional system it has been used for food, flavoring agents and form medicines. Keeping knowledge increasing demand drugs over their synthetic counter parts to restrain worldwide problem multidrug resistance (MDR) hepatoprotective activity. Neolamarckia cadamba that is commonly called Cadamb a standout amongst most significant therapeutic plants having place with Rubiaceae family. It one such Ayurvedic cure referenced numerous Indian restorative written works. The arrangement work includes gathering confirmation stem bark cadamb plant pursued by shade drying, granulating, extraction two-fold cool maceration, phytochemical examination lastly screening pharmacological exercises expressed. Aim: present study was carried out establish activity hydro alcoholic extract using two established hepatotoxic models Swiss albino mice (chloroform induced hepatotoxicity iron dose hepatotoxicity). Materials Methods: screened (NCHAE). experimental animals were treated corn oil chloroform period 7 days at 0.75mg/kg body weight, p.o induce hepatotoxicity. second model dextran hepatic damage performed administering 100 mg/kg, i.p.upto7 days, 3 consecutive periods. Blood samples collected estimation biochemical parameters histopathological changes liver also performed. Silymarin (50 mg/kg; weight) standard referral agent. Results: Chloroform treatment higher levels marker enzymes showed hepatocytes. findings there opposed dependently. results indicated produced both restored normal NCHAE. study, NCHAE found effect (***p<0.01) against inducing agents, which enhancement parameters. Conclusion: current confirmed likely related its potent antioxidant ironchelating property. therefore needs be further in-deep studies correlate bioactive constituents responsible selected. Key words: Hepatoprotective, cadamba, Chloroform, Iron dextran, Hepatotoxicity.